منابع مشابه
Proton Pump Inhibitors: More Indigestion than Relief?
Proton pump inhibitors (PPIs) are widely prescribed to treat a number of gastrointestinal (GI) disorders due to excessive acid production. While effective and safe, adverse renal effects have been increasingly described in epidemiological literature. The most well-documented adverse renal outcome is acute interstitial nephritis; however, association with overall acute kidney injury has also bee...
متن کاملInhibiting the proton pump: mechanisms, benefits, harms, and questions
Inhibition of the H+/K+-adenosine triphosphatase (the proton pump) is the final common mechanistic pathway in reducing gastric acid secretion pharmacologically. Proton pump inhibitors are widely used in upper gastrointestinal diseases, including gastric and duodenal ulcers, eradication of Helicobacter pylori in combination with antibiotics, gastroesophageal reflux disease, Zollinger-Ellison syn...
متن کاملThe vacuolar-type H⁺-ATPase at a glance - more than a proton pump.
The vacuolar H(+)-ATPase (V-ATPase) has long been appreciated to function as an electrogenic H(+) pump. By altering the pH of intracellular compartments, the V-ATPase dictates enzyme activity, governs the dissociation of ligands from receptors and promotes the coupled transport of substrates across membranes, a role often aided by the generation of a transmembrane electrical potential. In tissu...
متن کاملminocycline is more potent than tetracycline and doxycycline in inhibiting mmp-9 in vitro
conclusions our results suggest that tetracyclines dose-dependently inhibit mmp-9 activity, and among the common clinical tetracyclines, minocycline provides the most potent inhibition of excess mmp-9 activity and its consequences. materials and methods an mmp-9-rich culture medium of u-937 cells was used as the source of the enzyme. serial dilutions of 5, 20, 100, 200, and 500 µm of each drug ...
متن کاملNon-Specific Gastric Inflammation in Children is Associated with Proton Pump Inhibitor Treatment for More than 6 Weeks
BACKGROUND AND AIMS Non-specific gastric inflammation (NSGI) is a commonly reported pathological finding. We investigated if it is associated with the use of proton pump inhibitors (PPIs) in children at a single tertiary center. METHODS We performed an IRB-approved chart review of all endoscopy and biopsy reports of patients who underwent esophagogastroduodenoscopy between July 2009 and July ...
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ژورنال
عنوان ژورنال: Endocrine Abstracts
سال: 2015
ISSN: 1479-6848
DOI: 10.1530/endoabs.38.p36